A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

Yuwei HU; Feng CHEN; Hongfang LU; Susi TAN; Yujie KE; Wei Wei LOH; Eugene Jia Hao SOH; Agarwal TANIYA; Tommaso TABAGLIO; Dave Keng Boon WEE; Jackie Y. YING

doi:10.1039/d4cc01942c

A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

Yuwei HU^*, Feng CHEN, Hongfang LU, Susi TAN, Yujie KE, Wei Wei LOH, Eugene Jia Hao SOH, Agarwal TANIYA, Tommaso TABAGLIO, Dave Keng Boon WEE, Jackie Y. YING^*

^*Corresponding author for this work

School of Interdisciplinary Studies

Research output: Journal Publications › Journal Article (refereed) › peer-review

Abstract

A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.

Original language	English
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/d4cc01942c
Publication status	E-pub ahead of print - 12 Sept 2024

Access to Document

10.1039/d4cc01942c

Cite this

@article{d14df37f709d4fc19ae815f17aeccc7e,

title = "A splice-switch oligonucleotide loaded self-cleavable DNA nanogel",

abstract = "A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.",

author = "Yuwei HU and Feng CHEN and Hongfang LU and Susi TAN and Yujie KE and LOH, {Wei Wei} and SOH, {Eugene Jia Hao} and Agarwal TANIYA and Tommaso TABAGLIO and WEE, {Dave Keng Boon} and YING, {Jackie Y.}",

year = "2024",

month = sep,

day = "12",

doi = "10.1039/d4cc01942c",

language = "English",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

}

TY - JOUR

T1 - A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

AU - HU, Yuwei

AU - CHEN, Feng

AU - LU, Hongfang

AU - TAN, Susi

AU - KE, Yujie

AU - LOH, Wei Wei

AU - SOH, Eugene Jia Hao

AU - TANIYA, Agarwal

AU - TABAGLIO, Tommaso

AU - WEE, Dave Keng Boon

AU - YING, Jackie Y.

PY - 2024/9/12

Y1 - 2024/9/12

N2 - A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.

AB - A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.

U2 - 10.1039/d4cc01942c

DO - 10.1039/d4cc01942c

M3 - Journal Article (refereed)

C2 - 39308402

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

ER -