A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

Yuwei HU; Feng CHEN; Hongfang LU; Susi TAN; Yujie KE; Wei Wei LOH; Eugene Jia Hao SOH; Agarwal TANIYA; Tommaso TABAGLIO; Dave Keng Boon WEE; Jackie Y. YING

doi:10.1039/d4cc01942c

A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

Yuwei HU^*
, Feng CHEN
, Hongfang LU
, Susi TAN
, Yujie KE
, Wei Wei LOH
, Eugene Jia Hao SOH
, Agarwal TANIYA
, Tommaso TABAGLIO
, Dave Keng Boon WEE
, Jackie Y. YING^*

^*Corresponding author for this work

School of Interdisciplinary Studies

Research output: Journal Publications › Journal Article (refereed) › peer-review

Abstract

A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.

Original language	English
Pages (from-to)	11516-11519
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	81
Early online date	12 Sept 2024
DOIs	https://doi.org/10.1039/d4cc01942c
Publication status	Published - 8 Oct 2024

Bibliographical note

Publisher Copyright:
© 2024 The Royal Society of Chemistry.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/d4cc01942c

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title = "A splice-switch oligonucleotide loaded self-cleavable DNA nanogel",

abstract = "A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.",

author = "Yuwei HU and Feng CHEN and Hongfang LU and Susi TAN and Yujie KE and LOH, \{Wei Wei\} and SOH, \{Eugene Jia Hao\} and Agarwal TANIYA and Tommaso TABAGLIO and WEE, \{Dave Keng Boon\} and YING, \{Jackie Y.\}",

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year = "2024",

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day = "8",

doi = "10.1039/d4cc01942c",

language = "English",

volume = "60",

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journal = "Chemical Communications",

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TY - JOUR

T1 - A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

AU - HU, Yuwei

AU - CHEN, Feng

AU - LU, Hongfang

AU - TAN, Susi

AU - KE, Yujie

AU - LOH, Wei Wei

AU - SOH, Eugene Jia Hao

AU - TANIYA, Agarwal

AU - TABAGLIO, Tommaso

AU - WEE, Dave Keng Boon

AU - YING, Jackie Y.

PY - 2024/10/8

Y1 - 2024/10/8

N2 - A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.

AB - A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.

UR - https://www.scopus.com/pages/publications/85205772680

U2 - 10.1039/d4cc01942c

DO - 10.1039/d4cc01942c

M3 - Journal Article (refereed)

C2 - 39308402

SN - 1359-7345

VL - 60

SP - 11516

EP - 11519

JO - Chemical Communications

JF - Chemical Communications

IS - 81

ER -

A splice-switch oligonucleotide loaded self-cleavable DNA nanogel

Abstract

Bibliographical note

UN SDGs

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