With the rapid development of biclustering techniques in machine learning and data mining, such techniques have been successfully applied to practical problems such as gene expression analysis, text mining, collaborative filtering and market analysis. In this work, biclustering techniques were applied to segmentation of gray-scale human face images. A biclustering-based framework (BISA), which iteratively partitions an image into subimages/regions in the SVD subspaces and retains those passing the threshold test as effective regions (ERs), was proposed. After the third iteration of BISA in our experiments, most of important facial feature areas were captured and outputted as ERs, which can be further handled by feature-extraction or contour-detection tools. Overall, the proposed framework is useful and efficient in human face detection and facial feature area extraction, and it welcomes other biclustering methods as components for multi-purpose applications.