The COVID-19 pandemic occurred over two years and has not yet been finished. There are some possible Chinese medicines formulations used to prevent and treat COVID-19. Single pure herbal such as curcumin is the most common to combat SARS-CoV-2 with antioxidant, anti-inflammatory, antibacterial, antiviral, antitumor, and hepatoprotective properties. This short communication describes another single pure herbal, “Celastrol”, research progress and its nanosystem for the treatment of COVID-19.
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