Design, Synthesis and Characterization of Novel Curcumin Derivatives

Siukan LAW, Chuiman LO, Jie HAN, Fanwen YANG, Albert Wingnang LEUNG, Chuanshan XU*

*Corresponding author for this work

Research output: Journal PublicationsJournal Article (refereed)

Abstract

Curcumin is a substance in turmeric. It’s an active compound from natural plant Curcuma longa L which is widely used as an herbal medicine in Asian countries. The anti-inflammatory, antioxidant and anticancer properties that slow down the spread of cancer, makes chemotherapy more effective and protect healthy cells from damage by radiation therapy. However, it’s poor water, plasma solubility and bioavailability for human absorption. To overcome these problems, structural modification is attracting scientist’s attention.

In the present study, several curcumin derivatives including ferulic acid curcumin, isovanillin curcumin, 4-methoxy-1-naphthaldehyde curcumin, 3,5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, syringaldehyde curcumin, ibuprofen curcumin were designed and synthesized successfully with the percentage yield of 15.0%, 29.6%, 52.0%, 23.0%, 13.0% and 11.0% respectively.
Original languageEnglish
Article number367
Number of pages17
JournalNatural Products Chemistry and Research
Volume8
Issue number1
Publication statusPublished - 8 Jan 2020

Fingerprint

Curcumin
Derivatives
ferulic acid
Chemotherapy
Ibuprofen
Radiotherapy
Anti-Inflammatory Agents
Solubility
Antioxidants
Cells
Plasmas
Water

Bibliographical note

This work was supported by Innovation and Technology Fund of Shenzhen (JCYJ20170307165459562) and Science and Technology Project of Guangdong Province (2017B090911012). We expressed thanks to Prof. Hung-Kay LEE provided his laboratory space for synthesizing curcumin derivatives.

Keywords

  • Turneric
  • Curcuma longa L
  • Structural modification
  • Curcumin derivatives

Cite this

LAW, Siukan ; LO, Chuiman ; HAN, Jie ; YANG, Fanwen ; LEUNG, Albert Wingnang ; XU, Chuanshan. / Design, Synthesis and Characterization of Novel Curcumin Derivatives. In: Natural Products Chemistry and Research. 2020 ; Vol. 8, No. 1.
@article{878d6ef00776440481fbbdd8fff04ed3,
title = "Design, Synthesis and Characterization of Novel Curcumin Derivatives",
abstract = "Curcumin is a substance in turmeric. It’s an active compound from natural plant Curcuma longa L which is widely used as an herbal medicine in Asian countries. The anti-inflammatory, antioxidant and anticancer properties that slow down the spread of cancer, makes chemotherapy more effective and protect healthy cells from damage by radiation therapy. However, it’s poor water, plasma solubility and bioavailability for human absorption. To overcome these problems, structural modification is attracting scientist’s attention.In the present study, several curcumin derivatives including ferulic acid curcumin, isovanillin curcumin, 4-methoxy-1-naphthaldehyde curcumin, 3,5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, syringaldehyde curcumin, ibuprofen curcumin were designed and synthesized successfully with the percentage yield of 15.0{\%}, 29.6{\%}, 52.0{\%}, 23.0{\%}, 13.0{\%} and 11.0{\%} respectively.",
keywords = "Turneric, Curcuma longa L, Structural modification, Curcumin derivatives",
author = "Siukan LAW and Chuiman LO and Jie HAN and Fanwen YANG and LEUNG, {Albert Wingnang} and Chuanshan XU",
note = "This work was supported by Innovation and Technology Fund of Shenzhen (JCYJ20170307165459562) and Science and Technology Project of Guangdong Province (2017B090911012). We expressed thanks to Prof. Hung-Kay LEE provided his laboratory space for synthesizing curcumin derivatives.",
year = "2020",
month = "1",
day = "8",
language = "English",
volume = "8",
journal = "Natural Products Chemistry and Research",
issn = "2329-6836",
publisher = "Longdom Publishing",
number = "1",

}

Design, Synthesis and Characterization of Novel Curcumin Derivatives. / LAW, Siukan; LO, Chuiman; HAN, Jie; YANG, Fanwen; LEUNG, Albert Wingnang; XU, Chuanshan.

In: Natural Products Chemistry and Research, Vol. 8, No. 1, 367, 08.01.2020.

Research output: Journal PublicationsJournal Article (refereed)

TY - JOUR

T1 - Design, Synthesis and Characterization of Novel Curcumin Derivatives

AU - LAW, Siukan

AU - LO, Chuiman

AU - HAN, Jie

AU - YANG, Fanwen

AU - LEUNG, Albert Wingnang

AU - XU, Chuanshan

N1 - This work was supported by Innovation and Technology Fund of Shenzhen (JCYJ20170307165459562) and Science and Technology Project of Guangdong Province (2017B090911012). We expressed thanks to Prof. Hung-Kay LEE provided his laboratory space for synthesizing curcumin derivatives.

PY - 2020/1/8

Y1 - 2020/1/8

N2 - Curcumin is a substance in turmeric. It’s an active compound from natural plant Curcuma longa L which is widely used as an herbal medicine in Asian countries. The anti-inflammatory, antioxidant and anticancer properties that slow down the spread of cancer, makes chemotherapy more effective and protect healthy cells from damage by radiation therapy. However, it’s poor water, plasma solubility and bioavailability for human absorption. To overcome these problems, structural modification is attracting scientist’s attention.In the present study, several curcumin derivatives including ferulic acid curcumin, isovanillin curcumin, 4-methoxy-1-naphthaldehyde curcumin, 3,5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, syringaldehyde curcumin, ibuprofen curcumin were designed and synthesized successfully with the percentage yield of 15.0%, 29.6%, 52.0%, 23.0%, 13.0% and 11.0% respectively.

AB - Curcumin is a substance in turmeric. It’s an active compound from natural plant Curcuma longa L which is widely used as an herbal medicine in Asian countries. The anti-inflammatory, antioxidant and anticancer properties that slow down the spread of cancer, makes chemotherapy more effective and protect healthy cells from damage by radiation therapy. However, it’s poor water, plasma solubility and bioavailability for human absorption. To overcome these problems, structural modification is attracting scientist’s attention.In the present study, several curcumin derivatives including ferulic acid curcumin, isovanillin curcumin, 4-methoxy-1-naphthaldehyde curcumin, 3,5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, syringaldehyde curcumin, ibuprofen curcumin were designed and synthesized successfully with the percentage yield of 15.0%, 29.6%, 52.0%, 23.0%, 13.0% and 11.0% respectively.

KW - Turneric

KW - Curcuma longa L

KW - Structural modification

KW - Curcumin derivatives

M3 - Journal Article (refereed)

VL - 8

JO - Natural Products Chemistry and Research

JF - Natural Products Chemistry and Research

SN - 2329-6836

IS - 1

M1 - 367

ER -