Design, Synthesis and Characterization of Novel Curcumin Derivatives

Siukan LAW; Chuiman LO; Jie HAN; Fanwen YANG; Albert Wingnang LEUNG; Chuanshan XU

Design, Synthesis and Characterization of Novel Curcumin Derivatives

Siukan LAW, Chuiman LO, Jie HAN, Fanwen YANG, Albert Wingnang LEUNG, Chuanshan XU^*

^*Corresponding author for this work

Asia-Pacific Institute of Ageing Studies

Research output: Journal Publications › Journal Article (refereed) › peer-review

Abstract

Curcumin is a substance in turmeric. It’s an active compound from natural plant Curcuma longa L which is widely used as an herbal medicine in Asian countries. The anti-inflammatory, antioxidant and anticancer properties that slow down the spread of cancer, makes chemotherapy more effective and protect healthy cells from damage by radiation therapy. However, it’s poor water, plasma solubility and bioavailability for human absorption. To overcome these problems, structural modification is attracting scientist’s attention.

In the present study, several curcumin derivatives including ferulic acid curcumin, isovanillin curcumin, 4-methoxy-1-naphthaldehyde curcumin, 3,5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, syringaldehyde curcumin, ibuprofen curcumin were designed and synthesized successfully with the percentage yield of 15.0%, 29.6%, 52.0%, 23.0%, 13.0% and 11.0% respectively.

Original language	English
Article number	367
Number of pages	17
Journal	Natural Products Chemistry and Research
Volume	8
Issue number	1
Publication status	Published - 8 Jan 2020

Bibliographical note

This work was supported by Innovation and Technology Fund of Shenzhen (JCYJ20170307165459562) and Science and Technology Project of Guangdong Province (2017B090911012). We expressed thanks to Prof. Hung-Kay LEE provided his laboratory space for synthesizing curcumin derivatives.

Keywords

Turneric
Curcuma longa L
Structural modification
Curcumin derivatives

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Design, Synthesis and Characterization of Novel Curcumin Derivatives",

abstract = "Curcumin is a substance in turmeric. It{\textquoteright}s an active compound from natural plant Curcuma longa L which is widely used as an herbal medicine in Asian countries. The anti-inflammatory, antioxidant and anticancer properties that slow down the spread of cancer, makes chemotherapy more effective and protect healthy cells from damage by radiation therapy. However, it{\textquoteright}s poor water, plasma solubility and bioavailability for human absorption. To overcome these problems, structural modification is attracting scientist{\textquoteright}s attention.In the present study, several curcumin derivatives including ferulic acid curcumin, isovanillin curcumin, 4-methoxy-1-naphthaldehyde curcumin, 3,5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, syringaldehyde curcumin, ibuprofen curcumin were designed and synthesized successfully with the percentage yield of 15.0%, 29.6%, 52.0%, 23.0%, 13.0% and 11.0% respectively.",

keywords = "Turneric, Curcuma longa L, Structural modification, Curcumin derivatives",

author = "Siukan LAW and Chuiman LO and Jie HAN and Fanwen YANG and LEUNG, {Albert Wingnang} and Chuanshan XU",

note = "This work was supported by Innovation and Technology Fund of Shenzhen (JCYJ20170307165459562) and Science and Technology Project of Guangdong Province (2017B090911012). We expressed thanks to Prof. Hung-Kay LEE provided his laboratory space for synthesizing curcumin derivatives.",

year = "2020",

month = jan,

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language = "English",

volume = "8",

journal = "Natural Products Chemistry and Research",

issn = "2329-6836",

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TY - JOUR

T1 - Design, Synthesis and Characterization of Novel Curcumin Derivatives

AU - LAW, Siukan

AU - LO, Chuiman

AU - HAN, Jie

AU - YANG, Fanwen

AU - LEUNG, Albert Wingnang

AU - XU, Chuanshan

N1 - This work was supported by Innovation and Technology Fund of Shenzhen (JCYJ20170307165459562) and Science and Technology Project of Guangdong Province (2017B090911012). We expressed thanks to Prof. Hung-Kay LEE provided his laboratory space for synthesizing curcumin derivatives.

PY - 2020/1/8

Y1 - 2020/1/8

N2 - Curcumin is a substance in turmeric. It’s an active compound from natural plant Curcuma longa L which is widely used as an herbal medicine in Asian countries. The anti-inflammatory, antioxidant and anticancer properties that slow down the spread of cancer, makes chemotherapy more effective and protect healthy cells from damage by radiation therapy. However, it’s poor water, plasma solubility and bioavailability for human absorption. To overcome these problems, structural modification is attracting scientist’s attention.In the present study, several curcumin derivatives including ferulic acid curcumin, isovanillin curcumin, 4-methoxy-1-naphthaldehyde curcumin, 3,5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, syringaldehyde curcumin, ibuprofen curcumin were designed and synthesized successfully with the percentage yield of 15.0%, 29.6%, 52.0%, 23.0%, 13.0% and 11.0% respectively.

AB - Curcumin is a substance in turmeric. It’s an active compound from natural plant Curcuma longa L which is widely used as an herbal medicine in Asian countries. The anti-inflammatory, antioxidant and anticancer properties that slow down the spread of cancer, makes chemotherapy more effective and protect healthy cells from damage by radiation therapy. However, it’s poor water, plasma solubility and bioavailability for human absorption. To overcome these problems, structural modification is attracting scientist’s attention.In the present study, several curcumin derivatives including ferulic acid curcumin, isovanillin curcumin, 4-methoxy-1-naphthaldehyde curcumin, 3,5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, syringaldehyde curcumin, ibuprofen curcumin were designed and synthesized successfully with the percentage yield of 15.0%, 29.6%, 52.0%, 23.0%, 13.0% and 11.0% respectively.

KW - Turneric

KW - Curcuma longa L

KW - Structural modification

KW - Curcumin derivatives

M3 - Journal Article (refereed)

SN - 2329-6836

VL - 8

JO - Natural Products Chemistry and Research

JF - Natural Products Chemistry and Research

IS - 1

M1 - 367

ER -

Design, Synthesis and Characterization of Novel Curcumin Derivatives

Abstract

Bibliographical note

Keywords

UN SDGs

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