Design, Synthesis and Characterization of Novel Curcumin Derivatives

Siukan LAW, Chuiman LO, Jie HAN, Fanwen YANG, Albert Wingnang LEUNG, Chuanshan XU*

*Corresponding author for this work

Research output: Journal PublicationsJournal Article (refereed)peer-review


Curcumin is a substance in turmeric. It’s an active compound from natural plant Curcuma longa L which is widely used as an herbal medicine in Asian countries. The anti-inflammatory, antioxidant and anticancer properties that slow down the spread of cancer, makes chemotherapy more effective and protect healthy cells from damage by radiation therapy. However, it’s poor water, plasma solubility and bioavailability for human absorption. To overcome these problems, structural modification is attracting scientist’s attention.

In the present study, several curcumin derivatives including ferulic acid curcumin, isovanillin curcumin, 4-methoxy-1-naphthaldehyde curcumin, 3,5-di-tert-butyl-4-hydroxybenzaldehyde curcumin, syringaldehyde curcumin, ibuprofen curcumin were designed and synthesized successfully with the percentage yield of 15.0%, 29.6%, 52.0%, 23.0%, 13.0% and 11.0% respectively.
Original languageEnglish
Article number367
Number of pages17
JournalNatural Products Chemistry and Research
Issue number1
Publication statusPublished - 8 Jan 2020

Bibliographical note

This work was supported by Innovation and Technology Fund of Shenzhen (JCYJ20170307165459562) and Science and Technology Project of Guangdong Province (2017B090911012). We expressed thanks to Prof. Hung-Kay LEE provided his laboratory space for synthesizing curcumin derivatives.


  • Turneric
  • Curcuma longa L
  • Structural modification
  • Curcumin derivatives


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