Double-Domain Driven Unet for Selective Segmentation of Medical Image

  • Zhi-Feng PANG
  • , Lin YANG
  • , Mingxiang WU
  • , Ziyu NIU
  • , Raymond CHAN
  • , Xue-Cheng TAI*
  • *Corresponding author for this work

Research output: Journal PublicationsJournal Article (refereed)peer-review

Abstract

Selective segmentation has been a notable increase in interest in the use of interactive deep learning-based methods. However, developing an efficient and accurate segmentation method for medical applications remains a formidable challenge, primarily due to the inherent complexity and diversity of medical image structures. To address these challenges, we introduce a novel deep learning approach, termed the double-domain driven Unet method (DDUM),designed for the selective segmentation of medical images. Our approachutilizes a threshold geodesic distance in conjunction with the original images as input to construct a parallel Unet architecture that captures information from both the image domain and the geodesic distance domain. To further enhance the accuracy and efficacy of the segmentation process, we employ soft threshold dynamics as a replacement for the sigmoid activation function in the final layer. The efficacy of our proposed DDUM is substantiated through extensive experiments conducted on multiple medical image datasets. In particular, the DDUM method exhibits exceptional performance in terms of both segmentation accuracy and robustness.
Original languageEnglish
Number of pages29
JournalCSIAM Transactions on Applied Mathematics
Early online date4 Dec 2025
DOIs
Publication statusE-pub ahead of print - 4 Dec 2025

Funding

This work was supported in part by the Natural Science Foundation of China (Grant No. 12471398), by the Natural Science Foundation of Henan Province (Grant No. 232300420108), by the Key Scientific Research Projects in Universities in Henan Province (No. 24B110004), by the Henan Province International Science and Technology Cooperation (Project No. 242102520038), by the CityU1101120, CityU11309 922, NSFC/RGC (Grant No. NHKBU21419), by the CRF Grant C1013-21GF and by the NORCE Kompetanseoppbygging program, by the HKRGC (Grant Nos. CityU11309922, LU13300125), by the ITF (Grant Nos. MHP/054/22, LU BGR 105824), and by the InnoHK-Hong Kong Centre for Cerebro-cardiovascular Health Engineering.

Keywords

  • Image segmentation
  • regions of interest
  • threshold geodesic distance
  • double-domain driven Unet method
  • soft threshold dynamics

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