Effective electrical stimulation by a Poly(L-lactic acid)/Vitamin B2-Based piezoelectric generator promotes wound healing

Zhen ZHANG, Liming WANG, Qian ZHANG, Hongkun LI, Yong XIANG, Xinyu WANG*, Xiaoran HU

*Corresponding author for this work

Research output: Journal PublicationsJournal Article (refereed)peer-review

6 Citations (Scopus)


Chronic wounds pose an increasing burden not only to patients, but also to the health system. Wound repair requires the timely and orderly migration of fibroblasts to the wound bed. In this respect, electrical stimulation by a piezoelectric generator (PEG) is an attractive approach to wound management because it is noninvasive and effective in promoting chronic wound healing. However, commonly used PEGs based on polyvinylidenefluoride (PVDF) and poly(L-lactic acid) (PLLA) suffer from low biocompatibility and low piezoelectric output, respectively. Herein, we developed a bio-based PEG composed of PLLA blended with vitamin B2 (VB2), leading to an improvement of crystallinity and β-phase orientation, which exhibited better biocompatibility than PVDF and a higher piezoelectric output than pure PLLA. Such piezoelectricity could serve as effective electrical stimulation and promoted in vitro cell migration and fibroblast proliferation, evidenced by significant higher gene expression levels of extracellular matrix proteins and growth factors. Moreover, it facilitated in vivo wound closure by enhancing the re-epithelialization, collagen deposition, neovascularization, and increase the concentration of growth factors in the wound bed, leading to a 1.4-fold higher wound closure rate than that in the control group. Thus, the PLLA/VB2 PEG opens an avenue for the application of bio-based PEGs for wound healing.

Original languageEnglish
Article number111962
Number of pages9
JournalEuropean Polymer Journal
Publication statusPublished - 8 May 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Ltd


  • Biocompatibility
  • Electrical stimulation
  • Piezoelectric generator
  • Poly(L-lactic acid)
  • Vitamin B
  • Wound healing


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