Abstract
Introduction As the largest and most rapidly ageing population, Chinese people are now the major driver of the continued growth in dementia prevalence globally. The need for evidence-based interventions in Chinese communities is urgent. Although a wide range of pharmacological and non-pharmacological interventions for dementia have been trialled in Chinese populations, the evidence has not been systematically synthesised. This systematic review and meta-analysis aims to map out the interventions for people living with dementia and their carers in Chinese communities worldwide and compare the effectiveness of these interventions.
Methods and analysis This protocol followed the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols checklist. We will search Chinese (China National Knowledge Infrastructure, WanFang DATA) and English bibliographical databases (MEDLINE, EMBASE, PsycINFO, CINAHL Plus, Global Health, WHO Global Index Medicus, Virtual Health Library, Cochrane CENTRAL, Social Care Online, BASE, MODelling Outcome and cost impacts of interventions for DEMentia (MODEM) Toolkit, Cochrane Database of Systematic Reviews), complemented by hand searching of reference lists. We will include studies evaluating the effectiveness of interventions for dementia or mild cognitive impairment in Chinese populations, using a randomised controlled trial design, and published between January 2008 and June 2020. We will use a standardised form to extract data and Version 2 of the Cochrane risk-of-bias tool for randomised trials to assess the risk of bias of the included studies. Collected data will be fully interpreted with narrative synthesis and analysed using pairwise and network meta-analyses to pool intervention effects where sufficient information is available. We will perform subgroup analysis and meta-regression to explore potential reasons for heterogeneity.
Ethics and dissemination No formal ethics approval is required for this protocol. The findings will facilitate the development of studies on interventions for dementia and timely inform dementia policymaking and practice. Planned dissemination channels include peer-reviewed publications, conference presentations, public events and websites.
PROSPERO registration number CRD42019134135.
| Original language | English |
|---|---|
| Article number | e047560 |
| Number of pages | 9 |
| Journal | BMJ Open |
| Volume | 11 |
| Issue number | 8 |
| Early online date | 17 Aug 2021 |
| DOIs | |
| Publication status | Published - Aug 2021 |
| Externally published | Yes |
Funding
This work is conducted as part of the ‘Tools to Inform Policy: Chinese Communities Actions in Response to Dementia’ (TIP-CARD) project, supported by the Hong Kong Research Impact Fund of the Research Grants Council (Project Reference Number: R7017-18). MS-K, DMD, MK and AC-H’s contributions were supported by the UK Research and Innovation’s Global Challenges Research Fund (ES/P010938/1) as part of the ‘Strengthening Responses to Dementia in Developing Countries’ (STRiDE) project.
