Effects of apolipoprotein e on dementia and aging in the shanghai survey of dementia

R. KATZMAN, M.-Y. ZHANG, P. J. CHEN, N. GU, S. JIANG, T. SAITOH, X. CHEN, M. KLAUBER, R. G. THOMAS, W. T. LIU, E. S. H. YU

Research output: Journal PublicationsJournal Article (refereed)Researchpeer-review

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Abstract

We investigated the status of the apolipoprotein E allele in 538 participants in the incidence phase of the ongoing Shanghai Survey of Dementia, including 103 demented subjects, 72 with mild cognitive impairment and 363 cognitively normal. The apo E ε4 allele was present in 10.2% of control subjects and the allelic frequency did not change between ages 60 to 96 years. The apo E ε4 allelic frequency was increased both in those with Alzheimer's disease (AD) (25.4%) and those with vascular dementia (VaD) (22.2%), but not in those with other dementing illnesses or the cognitively impaired. All of the subjects homozygous for apo E ε4 were demented, three were diagnosed as having AD, and three met NINDS/AIREN criteria for VaD. The increased apo E ε4 allelic frequency in clinically diagnosed VaD patients suggests that some of the infarcts are secondary to congophilic angiopathy. The adjusted odds ratio of developing AD in this community-derived study for persons with at least one apo E ε4 allele was 4.1 (95% CI: 2.2, 7.7). Thus, the apo E ε4 risk of developing AD in this Chinese cohort is similar to that in western community studies.
Original languageEnglish
Pages (from-to)779-785
Number of pages7
JournalNeurology
Volume49
Issue number3
DOIs
Publication statusPublished - 1 Sep 1997
Externally publishedYes

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Apolipoprotein E4
Apolipoproteins
Dementia
Vascular Dementia
Alzheimer Disease
Alleles
National Institute of Neurological Disorders and Stroke
Cerebral Amyloid Angiopathy
Apolipoproteins E
Surveys and Questionnaires
Odds Ratio
Incidence

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KATZMAN, R., ZHANG, M-Y., CHEN, P. J., GU, N., JIANG, S., SAITOH, T., ... YU, E. S. H. (1997). Effects of apolipoprotein e on dementia and aging in the shanghai survey of dementia. Neurology, 49(3), 779-785. https://doi.org/10.1212/WNL.49.3.779
KATZMAN, R. ; ZHANG, M.-Y. ; CHEN, P. J. ; GU, N. ; JIANG, S. ; SAITOH, T. ; CHEN, X. ; KLAUBER, M. ; THOMAS, R. G. ; LIU, W. T. ; YU, E. S. H. / Effects of apolipoprotein e on dementia and aging in the shanghai survey of dementia. In: Neurology. 1997 ; Vol. 49, No. 3. pp. 779-785.
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abstract = "We investigated the status of the apolipoprotein E allele in 538 participants in the incidence phase of the ongoing Shanghai Survey of Dementia, including 103 demented subjects, 72 with mild cognitive impairment and 363 cognitively normal. The apo E ε4 allele was present in 10.2{\%} of control subjects and the allelic frequency did not change between ages 60 to 96 years. The apo E ε4 allelic frequency was increased both in those with Alzheimer's disease (AD) (25.4{\%}) and those with vascular dementia (VaD) (22.2{\%}), but not in those with other dementing illnesses or the cognitively impaired. All of the subjects homozygous for apo E ε4 were demented, three were diagnosed as having AD, and three met NINDS/AIREN criteria for VaD. The increased apo E ε4 allelic frequency in clinically diagnosed VaD patients suggests that some of the infarcts are secondary to congophilic angiopathy. The adjusted odds ratio of developing AD in this community-derived study for persons with at least one apo E ε4 allele was 4.1 (95{\%} CI: 2.2, 7.7). Thus, the apo E ε4 risk of developing AD in this Chinese cohort is similar to that in western community studies.",
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KATZMAN, R, ZHANG, M-Y, CHEN, PJ, GU, N, JIANG, S, SAITOH, T, CHEN, X, KLAUBER, M, THOMAS, RG, LIU, WT & YU, ESH 1997, 'Effects of apolipoprotein e on dementia and aging in the shanghai survey of dementia', Neurology, vol. 49, no. 3, pp. 779-785. https://doi.org/10.1212/WNL.49.3.779

Effects of apolipoprotein e on dementia and aging in the shanghai survey of dementia. / KATZMAN, R.; ZHANG, M.-Y.; CHEN, P. J.; GU, N.; JIANG, S.; SAITOH, T.; CHEN, X.; KLAUBER, M.; THOMAS, R. G.; LIU, W. T.; YU, E. S. H.

In: Neurology, Vol. 49, No. 3, 01.09.1997, p. 779-785.

Research output: Journal PublicationsJournal Article (refereed)Researchpeer-review

TY - JOUR

T1 - Effects of apolipoprotein e on dementia and aging in the shanghai survey of dementia

AU - KATZMAN, R.

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AU - CHEN, P. J.

AU - GU, N.

AU - JIANG, S.

AU - SAITOH, T.

AU - CHEN, X.

AU - KLAUBER, M.

AU - THOMAS, R. G.

AU - LIU, W. T.

AU - YU, E. S. H.

PY - 1997/9/1

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N2 - We investigated the status of the apolipoprotein E allele in 538 participants in the incidence phase of the ongoing Shanghai Survey of Dementia, including 103 demented subjects, 72 with mild cognitive impairment and 363 cognitively normal. The apo E ε4 allele was present in 10.2% of control subjects and the allelic frequency did not change between ages 60 to 96 years. The apo E ε4 allelic frequency was increased both in those with Alzheimer's disease (AD) (25.4%) and those with vascular dementia (VaD) (22.2%), but not in those with other dementing illnesses or the cognitively impaired. All of the subjects homozygous for apo E ε4 were demented, three were diagnosed as having AD, and three met NINDS/AIREN criteria for VaD. The increased apo E ε4 allelic frequency in clinically diagnosed VaD patients suggests that some of the infarcts are secondary to congophilic angiopathy. The adjusted odds ratio of developing AD in this community-derived study for persons with at least one apo E ε4 allele was 4.1 (95% CI: 2.2, 7.7). Thus, the apo E ε4 risk of developing AD in this Chinese cohort is similar to that in western community studies.

AB - We investigated the status of the apolipoprotein E allele in 538 participants in the incidence phase of the ongoing Shanghai Survey of Dementia, including 103 demented subjects, 72 with mild cognitive impairment and 363 cognitively normal. The apo E ε4 allele was present in 10.2% of control subjects and the allelic frequency did not change between ages 60 to 96 years. The apo E ε4 allelic frequency was increased both in those with Alzheimer's disease (AD) (25.4%) and those with vascular dementia (VaD) (22.2%), but not in those with other dementing illnesses or the cognitively impaired. All of the subjects homozygous for apo E ε4 were demented, three were diagnosed as having AD, and three met NINDS/AIREN criteria for VaD. The increased apo E ε4 allelic frequency in clinically diagnosed VaD patients suggests that some of the infarcts are secondary to congophilic angiopathy. The adjusted odds ratio of developing AD in this community-derived study for persons with at least one apo E ε4 allele was 4.1 (95% CI: 2.2, 7.7). Thus, the apo E ε4 risk of developing AD in this Chinese cohort is similar to that in western community studies.

UR - http://commons.ln.edu.hk/sw_master/6961

U2 - 10.1212/WNL.49.3.779

DO - 10.1212/WNL.49.3.779

M3 - Journal Article (refereed)

VL - 49

SP - 779

EP - 785

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 3

ER -

KATZMAN R, ZHANG M-Y, CHEN PJ, GU N, JIANG S, SAITOH T et al. Effects of apolipoprotein e on dementia and aging in the shanghai survey of dementia. Neurology. 1997 Sep 1;49(3):779-785. https://doi.org/10.1212/WNL.49.3.779