Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: A 3-month prospective study

Yan LIANG; Yuen Lai CHAN; Min DENG; Yang Kun CHEN; Vincent MOK; De Feng WANG; Gabor S. UNGVARI; Chiu-wing Winnie CHU; Wai Kwong TANG

doi:10.1016/j.jad.2017.11.080

Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: A 3-month prospective study

Yan LIANG, Yuen Lai CHAN, Min DENG, Yang Kun CHEN, Vincent MOK, De Feng WANG, Gabor S. UNGVARI, Chiu-wing Winnie CHU^*, Wai Kwong TANG

^*Corresponding author for this work

Research output: Journal Publications › Journal Article (refereed) › peer-review

24 Citations (Scopus)

Abstract

Background

Enlarged perivascular spaces (EPVS), markers of cerebral small vessel disease, are associated with unfavorable prognosis of stroke. This study explored the relationship between EPVS and poststroke depression (PSD).

Methods

A total of 725 patients with acute ischemic stroke were recruited from the Stroke Unit of a university-affiliated hospital in Hong Kong. PSD was defined as a Geriatric Depression Scale score of ≥ 7 assessed at three months after stroke. The extent of EPVS in the basal ganglia (BG) and the centrum semiovale (CS) was assessed on axial T2 weighted magnetic resonance imaging using a validated scale. Patients’ EPVS status was categorized as either mild or moderate to severe degree. The association between EPVS and PSD was examined with logistic regression.

Results

One hundred and fifty-three (21.1%) of the study sample had PSD three month after stroke. 55.6% of the study sample were classified as having a minor stroke. The median scores of CS- and BG-EPVS were 1 (1−2) and 1 (0−2), respectively. After adjusting for demographic, clinical and imaging characteristics in multivariate logistic regression analyses, the CS-EPVS continuous score remained an independent predictor of PSD [odds ratio (OR) = 1.27; 95% confidence interval (CI) = 1.03–1.57]. After dichotomized, moderate to severe CS-EPVS was independently associated with PSD with an OR of 1.68 (95%CI = 1.10–2.57).

Limitations

The diagnosis of PSD was based on GDS score rather than a standardized clinical examination. The study favored the patients with milder stroke.

Conclusion

CS-EPVS were associated with PSD identified at three months after mild to moderate acute ischemic stroke.

Original language	English
Pages (from-to)	166-172
Number of pages	7
Journal	Journal of Affective Disorders
Volume	228
Early online date	22 Nov 2017
DOIs	https://doi.org/10.1016/j.jad.2017.11.080
Publication status	Published - 1 Mar 2018
Externally published	Yes

Bibliographical note

Acknowledgments:
We would like to thank Professor José Manuel Ferro for his valuable comments on the initial draft of the manuscript.

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

Cerebral small vessel disease
Depression
Perivascular spaces
Stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jad.2017.11.080

Cite this

@article{5ba98f49abaf470d98547704dd848250,

title = "Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: A 3-month prospective study",

abstract = "BackgroundEnlarged perivascular spaces (EPVS), markers of cerebral small vessel disease, are associated with unfavorable prognosis of stroke. This study explored the relationship between EPVS and poststroke depression (PSD).MethodsA total of 725 patients with acute ischemic stroke were recruited from the Stroke Unit of a university-affiliated hospital in Hong Kong. PSD was defined as a Geriatric Depression Scale score of ≥ 7 assessed at three months after stroke. The extent of EPVS in the basal ganglia (BG) and the centrum semiovale (CS) was assessed on axial T2 weighted magnetic resonance imaging using a validated scale. Patients{\textquoteright} EPVS status was categorized as either mild or moderate to severe degree. The association between EPVS and PSD was examined with logistic regression.ResultsOne hundred and fifty-three (21.1%) of the study sample had PSD three month after stroke. 55.6% of the study sample were classified as having a minor stroke. The median scores of CS- and BG-EPVS were 1 (1−2) and 1 (0−2), respectively. After adjusting for demographic, clinical and imaging characteristics in multivariate logistic regression analyses, the CS-EPVS continuous score remained an independent predictor of PSD [odds ratio (OR) = 1.27; 95% confidence interval (CI) = 1.03–1.57]. After dichotomized, moderate to severe CS-EPVS was independently associated with PSD with an OR of 1.68 (95%CI = 1.10–2.57).LimitationsThe diagnosis of PSD was based on GDS score rather than a standardized clinical examination. The study favored the patients with milder stroke.ConclusionCS-EPVS were associated with PSD identified at three months after mild to moderate acute ischemic stroke.",

keywords = "Cerebral small vessel disease, Depression, Perivascular spaces, Stroke",

author = "Yan LIANG and CHAN, {Yuen Lai} and Min DENG and CHEN, {Yang Kun} and Vincent MOK and WANG, {De Feng} and UNGVARI, {Gabor S.} and CHU, {Chiu-wing Winnie} and TANG, {Wai Kwong}",

note = "Acknowledgments: We would like to thank Professor Jos{\'e} Manuel Ferro for his valuable comments on the initial draft of the manuscript. Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2018",

month = mar,

day = "1",

doi = "10.1016/j.jad.2017.11.080",

language = "English",

volume = "228",

pages = "166--172",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

}

TY - JOUR

T1 - Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: A 3-month prospective study

AU - LIANG, Yan

AU - CHAN, Yuen Lai

AU - DENG, Min

AU - CHEN, Yang Kun

AU - MOK, Vincent

AU - WANG, De Feng

AU - UNGVARI, Gabor S.

AU - CHU, Chiu-wing Winnie

AU - TANG, Wai Kwong

PY - 2018/3/1

Y1 - 2018/3/1

N2 - BackgroundEnlarged perivascular spaces (EPVS), markers of cerebral small vessel disease, are associated with unfavorable prognosis of stroke. This study explored the relationship between EPVS and poststroke depression (PSD).MethodsA total of 725 patients with acute ischemic stroke were recruited from the Stroke Unit of a university-affiliated hospital in Hong Kong. PSD was defined as a Geriatric Depression Scale score of ≥ 7 assessed at three months after stroke. The extent of EPVS in the basal ganglia (BG) and the centrum semiovale (CS) was assessed on axial T2 weighted magnetic resonance imaging using a validated scale. Patients’ EPVS status was categorized as either mild or moderate to severe degree. The association between EPVS and PSD was examined with logistic regression.ResultsOne hundred and fifty-three (21.1%) of the study sample had PSD three month after stroke. 55.6% of the study sample were classified as having a minor stroke. The median scores of CS- and BG-EPVS were 1 (1−2) and 1 (0−2), respectively. After adjusting for demographic, clinical and imaging characteristics in multivariate logistic regression analyses, the CS-EPVS continuous score remained an independent predictor of PSD [odds ratio (OR) = 1.27; 95% confidence interval (CI) = 1.03–1.57]. After dichotomized, moderate to severe CS-EPVS was independently associated with PSD with an OR of 1.68 (95%CI = 1.10–2.57).LimitationsThe diagnosis of PSD was based on GDS score rather than a standardized clinical examination. The study favored the patients with milder stroke.ConclusionCS-EPVS were associated with PSD identified at three months after mild to moderate acute ischemic stroke.

AB - BackgroundEnlarged perivascular spaces (EPVS), markers of cerebral small vessel disease, are associated with unfavorable prognosis of stroke. This study explored the relationship between EPVS and poststroke depression (PSD).MethodsA total of 725 patients with acute ischemic stroke were recruited from the Stroke Unit of a university-affiliated hospital in Hong Kong. PSD was defined as a Geriatric Depression Scale score of ≥ 7 assessed at three months after stroke. The extent of EPVS in the basal ganglia (BG) and the centrum semiovale (CS) was assessed on axial T2 weighted magnetic resonance imaging using a validated scale. Patients’ EPVS status was categorized as either mild or moderate to severe degree. The association between EPVS and PSD was examined with logistic regression.ResultsOne hundred and fifty-three (21.1%) of the study sample had PSD three month after stroke. 55.6% of the study sample were classified as having a minor stroke. The median scores of CS- and BG-EPVS were 1 (1−2) and 1 (0−2), respectively. After adjusting for demographic, clinical and imaging characteristics in multivariate logistic regression analyses, the CS-EPVS continuous score remained an independent predictor of PSD [odds ratio (OR) = 1.27; 95% confidence interval (CI) = 1.03–1.57]. After dichotomized, moderate to severe CS-EPVS was independently associated with PSD with an OR of 1.68 (95%CI = 1.10–2.57).LimitationsThe diagnosis of PSD was based on GDS score rather than a standardized clinical examination. The study favored the patients with milder stroke.ConclusionCS-EPVS were associated with PSD identified at three months after mild to moderate acute ischemic stroke.

KW - Cerebral small vessel disease

KW - Depression

KW - Perivascular spaces

KW - Stroke

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U2 - 10.1016/j.jad.2017.11.080

DO - 10.1016/j.jad.2017.11.080

M3 - Journal Article (refereed)

C2 - 29253682

AN - SCOPUS:85038011987

SN - 0165-0327

VL - 228

SP - 166

EP - 172

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Enlarged perivascular spaces in the centrum semiovale are associated with poststroke depression: A 3-month prospective study

Abstract

Bibliographical note

Keywords

UN SDGs

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