Interaction with liquids at the ultra-large surface area of nanoporous material enables a high-efficiency energy dissipation system with wide perspective applications [A. Han, et al., Langmuir 2008, 24, 7044]. In this paper, a nanoporous energy dissipation system composed of a mixture of zeolite ZSM-5 and water is established and studied experimentally. Firstly, quasi-static compression experiments are carried out to analyze the pressure-volume curve and reveal the energy dissipation mechanism. Afterwards, a parametric study is conducted to explore the effects of three parameters, the pretreatment temperature of zeolite ZSM-5 (600-1100 °C), mass ratio of ZSM-5 to water (1:5-6:5), and average zeolite particle size (2.145-5.251 μm before heated or 6.104-9.557 μm after heated). Results show that in order to obtain optimum energy absorption performance, the pretreatment temperature of about 1000 °C, and higher ratio of ZSM-5 with larger particle size are desired. With high energy dissipation and reusability, the zeolite-water system with optimal parameters established herein may become an attractive cushioning device. Interaction with water at the ultra-large surface area of nanoporous material (zeolite ZSM-5) is utilized to establish a nanoporous energy dissipation system and studied experimentally in this paper. Results show that the pretreatment temperature of about 1000 °C, and higher ratio of ZSM-5 with larger particle size are desired for an optimum energy dissipation performance, which enables a reusable cushioning device.