Federated Domain Adaptation via Transformer for Multi-site Alzheimer’s Disease Diagnosis

Baiying LEI, Yun ZHU, Enmin LIANG, Peng YANG, Shaobin CHEN, Houyou HU, Haoran XIE, Ziyi WEI, Xuegang SONG, Tianfu WANG, Xiaohua XIAO, Shuqiang WANG, Hongbin HAN

Research output: Journal PublicationsJournal Article (refereed)peer-review

3 Citations (Scopus)


In multi-site studies of Alzheimer’s disease (AD), the difference of data in multi-site datasets leads to the degraded performance of models in the target sites. The traditional domain adaptation method requires sharing data from both source and target domains, which will lead to data privacy issue. To solve it, federated learning is adopted as it can allow models to be trained with multi-site data in a privacy-protected manner. In this paper, we propose a multi-site federated domain adaptation framework via Transformer (FedDAvT), which not only protects data privacy, but also eliminates data heterogeneity. The Transformer network is used as the backbone network to extract the correlation between the multi-template region of interest features, which can capture the brain abundant information. The self-attention maps in the source and target domains are aligned by applying mean squared error for subdomain adaptation. Finally, we evaluate our method on the multi-site databases based on three AD datasets. The experimental results show that the proposed FedDAvT is quite effective, achieving accuracy rates of 88.75%, 69.51%, and 69.88% on the AD vs. NC, MCI vs. NC, and AD vs. MCI two-way classification tasks, respectively.
Original languageEnglish
Pages (from-to)3651-3664
Number of pages14
JournalIEEE Transactions on Medical Imaging
Issue number12
Early online date1 Aug 2023
Publication statusPublished - 1 Dec 2023

Bibliographical note

Publisher Copyright:
© 1982-2012 IEEE.


  • Adaptation models
  • Alzheimer’s Disease
  • Data privacy
  • Domain Adaptation
  • Feature extraction
  • Federated Learning
  • Federated learning
  • Hospitals
  • Magnetic resonance imaging
  • Transformer
  • Transformers
  • transformer
  • domain adaptation
  • Alzheimer's disease
  • federated learning


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