TY - JOUR
T1 - Highly Biocompatible Polyester-Based Piezoelectric Elastomer with Antitumor and Antibacterial Activity for Ultrasound-Enhanced Piezoelectric Therapy
AU - DENG, Xiangtian
AU - ZHAO, Renliang
AU - TANG, Yunfeng
AU - YI, Min
AU - GE, Zilu
AU - WANG, Dong
AU - FANG, Qian
AU - XIONG, Zhencheng
AU - DUAN, Ao
AU - LIU, Wenzheng
AU - ZHANG, Zhen
AU - XIANG, Yong
AU - HU, Xiaoran
AU - LIN, Wei
AU - WANG, Guanglin
N1 - Publisher Copyright:
© 2023 American Chemical Society.
PY - 2023/12/6
Y1 - 2023/12/6
N2 - Currently, the use of piezoelectric materials to provide sustainable and noninvasive bioelectric stimulation to eradicate tumor cells and accelerate wound healing has raised wide attention. The development of a multifunctional piezoelectric elastomer with the ability to perform in situ tumor therapy as well as wound repair is of paramount importance. However, current piezoelectric materials have a large elastic modulus and limited stretchability, making it difficult to match with the dynamic curvature changes of the wound. Therefore, by copolymerizing lactic acid, butanediol, sebacic acid, and itaconic acid to develop a piezoelectric elastomer (PLBSIE), we construct a new ultrasound-activated PLBSIE-based tumor/wound unified therapeutic platform. Excitedly, it showed outstanding piezoelectric performance and high stretchability, and the separated carrier could react with water to generate highly cytotoxic reactive oxygen species (ROS), contributing to effectively killing tumor cells and eliminating bacteria through piezoelectric therapy. In addition, ultrasound-triggered piezoelectric effects could promote the migration and differentiation of wound-healing-related cells, thus accelerating wound healing. Herein, such a piezoelectric elastomer exerted a critical role in postoperative tumor-induced wound therapy and healing with the merits of possessing multifunctional abilities. Taken together, the developed ultrasound-activated PLBSIE will offer a comprehensive treatment for postoperative osteosarcoma therapy.
AB - Currently, the use of piezoelectric materials to provide sustainable and noninvasive bioelectric stimulation to eradicate tumor cells and accelerate wound healing has raised wide attention. The development of a multifunctional piezoelectric elastomer with the ability to perform in situ tumor therapy as well as wound repair is of paramount importance. However, current piezoelectric materials have a large elastic modulus and limited stretchability, making it difficult to match with the dynamic curvature changes of the wound. Therefore, by copolymerizing lactic acid, butanediol, sebacic acid, and itaconic acid to develop a piezoelectric elastomer (PLBSIE), we construct a new ultrasound-activated PLBSIE-based tumor/wound unified therapeutic platform. Excitedly, it showed outstanding piezoelectric performance and high stretchability, and the separated carrier could react with water to generate highly cytotoxic reactive oxygen species (ROS), contributing to effectively killing tumor cells and eliminating bacteria through piezoelectric therapy. In addition, ultrasound-triggered piezoelectric effects could promote the migration and differentiation of wound-healing-related cells, thus accelerating wound healing. Herein, such a piezoelectric elastomer exerted a critical role in postoperative tumor-induced wound therapy and healing with the merits of possessing multifunctional abilities. Taken together, the developed ultrasound-activated PLBSIE will offer a comprehensive treatment for postoperative osteosarcoma therapy.
KW - antibacterial
KW - antitumor
KW - osteosarcoma
KW - piezoelectric elastomer
KW - ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85179129614&partnerID=8YFLogxK
U2 - 10.1021/acsami.3c11749
DO - 10.1021/acsami.3c11749
M3 - Journal Article (refereed)
C2 - 37991726
AN - SCOPUS:85179129614
SN - 1944-8244
VL - 15
SP - 55308
EP - 55322
JO - ACS Applied Materials and Interfaces
JF - ACS Applied Materials and Interfaces
IS - 48
ER -