Abstract
Currently, the use of piezoelectric materials to provide sustainable and noninvasive bioelectric stimulation to eradicate tumor cells and accelerate wound healing has raised wide attention. The development of a multifunctional piezoelectric elastomer with the ability to perform in situ tumor therapy as well as wound repair is of paramount importance. However, current piezoelectric materials have a large elastic modulus and limited stretchability, making it difficult to match with the dynamic curvature changes of the wound. Therefore, by copolymerizing lactic acid, butanediol, sebacic acid, and itaconic acid to develop a piezoelectric elastomer (PLBSIE), we construct a new ultrasound-activated PLBSIE-based tumor/wound unified therapeutic platform. Excitedly, it showed outstanding piezoelectric performance and high stretchability, and the separated carrier could react with water to generate highly cytotoxic reactive oxygen species (ROS), contributing to effectively killing tumor cells and eliminating bacteria through piezoelectric therapy. In addition, ultrasound-triggered piezoelectric effects could promote the migration and differentiation of wound-healing-related cells, thus accelerating wound healing. Herein, such a piezoelectric elastomer exerted a critical role in postoperative tumor-induced wound therapy and healing with the merits of possessing multifunctional abilities. Taken together, the developed ultrasound-activated PLBSIE will offer a comprehensive treatment for postoperative osteosarcoma therapy.
Original language | English |
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Pages (from-to) | 55308-55322 |
Number of pages | 15 |
Journal | ACS Applied Materials and Interfaces |
Volume | 15 |
Issue number | 48 |
Early online date | 22 Nov 2023 |
DOIs | |
Publication status | Published - 6 Dec 2023 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2023 American Chemical Society.
Funding
This work was supported by the Natural Science Foundation of Sichuan (2023NSFSC1835), the Tibet Autonomous Region cofunded project (XZ202301ZY0046G), the Post-Doctor Research Project of West China Hospital, Sichuan University (2023HXBH106), and the China Postdoctoral Science Foundation (2023M732467, 2023TQ0224).
Keywords
- antibacterial
- antitumor
- osteosarcoma
- piezoelectric elastomer
- ultrasound