Highly Stretchable Piezoelectric Elastomer for Accelerated Repairing of Skeletal Muscles Loss

Qian FANG, Dong WANG, Wei LIN, Zilu GE, Xiangtian DENG, Renliang ZHAO, Yunfeng TANG, Wenzheng LIU, Zhencheng XIONG, Ao DUAN, Zhen ZHANG, Yong XIANG*, Xiaoran HU*, Guanglin WANG*

*Corresponding author for this work

Research output: Journal PublicationsJournal Article (refereed)peer-review

Abstract

Skeletal muscle loss is a common clinical disease, whose long treatment period and expensive treatment costs bring a heavy burden to patients. Currently, the use of piezoelectric materials to generate in situ and efficient electrical stimulation has been proven to significantly promote wound healing and other defects. However, skeletal muscle requires repaired materials with high elastic deformation to accompany its reciprocating movement during the healing process. Therefore, developing biocompatible materials that combine high piezoelectricity and stretchability is a great challenge. In the present work, a piezoelectric elastomer PPBE is prepared by copolymerization of bio-based diacid and diol. PPBE has matching elastic modulus with the skeletal muscle to accompanied proceed stretching and recovery movements. Piezoelectrical charge from PPBE scaffold under ultrasound and mechanical stimuli could promote myogenic differentiation via Ca2+ signaling pathway and modulate cell functions, resulting in improved muscle morphology and functional performance of skeletal muscle. Thus, development of the degradable PPBE scaffold would provide new therapy strategy for volumetric muscle loss (VML) and present great potential in repairing of other tissues.

Original languageEnglish
Article number2313055
Number of pages16
JournalAdvanced Functional Materials
DOIs
Publication statusE-pub ahead of print - 21 Mar 2024
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2024 Wiley-VCH GmbH.

Keywords

  • accelerated repairing
  • biocompatibility
  • electric stimulations
  • piezoelectric elastomer
  • skeletal muscles loss

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