Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity

Baiyan SUI; Zhiyan XU; Zhiyu XUE; Yong XIANG; Tian ZHOU; Ana M. BELTRÁN; Kai ZHENG; Xin LIU; Aldo R. BOCCACCINI

doi:10.1021/acsami.3c03680

Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity

Baiyan SUI, Zhiyan XU, Zhiyu XUE, Yong XIANG, Tian ZHOU, Ana M. BELTRÁN, Kai ZHENG^*, Xin LIU^*, Aldo R. BOCCACCINI^*

^*Corresponding author for this work

Research output: Journal Publications › Journal Article (refereed) › peer-review

2 Citations (Scopus)

Abstract

Exploring new approaches to realize the possibility of incorporating biologically active elements into mesoporous silicate bioactive glass nanoparticles (MBG NPs) and guaranteeing their meso- structural integrity and dimensional stability has become an attractive and interesting challenge in biomaterials science. We present a postgrafting strategy for introducing different metal elements into MBG NPs. This strategy is mediated by polydopamine (PDA) coating, achieving uniform loading of copper or copper-cobalt on the particles efficiently and ensuring the stability of MBG NPs in terms of particle size, mesoporous structure, and chemical structure. However, the PDA coating reduced the ion-binding free energy of the MBG NPs for calcium and phosphate ions, resulting in the deposition of minimal CaP clusters on the PDA@MBG NP surface when immersed for 7 days in simulated body fluid, indicating the absence of hydroxyapatite mineralization.

Original language	English
Pages (from-to)	29550-29560
Number of pages	11
Journal	ACS Applied Materials and Interfaces
Volume	15
Issue number	24
Early online date	6 Jun 2023
DOIs	https://doi.org/10.1021/acsami.3c03680
Publication status	Published - 21 Jun 2023
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2023 American Chemical Society.

Funding

This work was sponsored by grants from the National Natural Science Foundation of China (31900956 and 81971751), the Shanghai Pujiang Program (21PJD035), and the China Scholarship Council (CSC, no. 202006740028). The authors also thank CITIUS-Universidad de Sevilla (Spain) for the use of transmission electron microscopy facilities.

Keywords

biomineralization
mesoporous bioactive glass
metal-ion loading
molecular dynamics simulation
polydopamine coating

Access to Document

10.1021/acsami.3c03680

Cite this

SUI, B., XU, Z., XUE, Z., XIANG, Y., ZHOU, T., BELTRÁN, A. M., ZHENG, K., LIU, X., & BOCCACCINI, A. R. (2023). Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity. ACS Applied Materials and Interfaces, 15(24), 29550-29560. https://doi.org/10.1021/acsami.3c03680

@article{a2d08eb7aed84d59904c31048a075561,

title = "Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity",

abstract = "Exploring new approaches to realize the possibility of incorporating biologically active elements into mesoporous silicate bioactive glass nanoparticles (MBG NPs) and guaranteeing their meso- structural integrity and dimensional stability has become an attractive and interesting challenge in biomaterials science. We present a postgrafting strategy for introducing different metal elements into MBG NPs. This strategy is mediated by polydopamine (PDA) coating, achieving uniform loading of copper or copper-cobalt on the particles efficiently and ensuring the stability of MBG NPs in terms of particle size, mesoporous structure, and chemical structure. However, the PDA coating reduced the ion-binding free energy of the MBG NPs for calcium and phosphate ions, resulting in the deposition of minimal CaP clusters on the PDA@MBG NP surface when immersed for 7 days in simulated body fluid, indicating the absence of hydroxyapatite mineralization.",

keywords = "biomineralization, mesoporous bioactive glass, metal-ion loading, molecular dynamics simulation, polydopamine coating",

author = "Baiyan SUI and Zhiyan XU and Zhiyu XUE and Yong XIANG and Tian ZHOU and BELTR{\'A}N, {Ana M.} and Kai ZHENG and Xin LIU and BOCCACCINI, {Aldo R.}",

note = "Publisher Copyright: {\textcopyright} 2023 American Chemical Society.",

year = "2023",

month = jun,

day = "21",

doi = "10.1021/acsami.3c03680",

language = "English",

volume = "15",

pages = "29550--29560",

journal = "ACS Applied Materials and Interfaces",

issn = "1944-8244",

publisher = "American Chemical Society",

number = "24",

}

SUI, B, XU, Z, XUE, Z, XIANG, Y, ZHOU, T, BELTRÁN, AM, ZHENG, K, LIU, X & BOCCACCINI, AR 2023, 'Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity', ACS Applied Materials and Interfaces, vol. 15, no. 24, pp. 29550-29560. https://doi.org/10.1021/acsami.3c03680

Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity. / SUI, Baiyan; XU, Zhiyan; XUE, Zhiyu et al.
In: ACS Applied Materials and Interfaces, Vol. 15, No. 24, 21.06.2023, p. 29550-29560.

Research output: Journal Publications › Journal Article (refereed) › peer-review

TY - JOUR

T1 - Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity

AU - SUI, Baiyan

AU - XU, Zhiyan

AU - XUE, Zhiyu

AU - XIANG, Yong

AU - ZHOU, Tian

AU - BELTRÁN, Ana M.

AU - ZHENG, Kai

AU - LIU, Xin

AU - BOCCACCINI, Aldo R.

PY - 2023/6/21

Y1 - 2023/6/21

N2 - Exploring new approaches to realize the possibility of incorporating biologically active elements into mesoporous silicate bioactive glass nanoparticles (MBG NPs) and guaranteeing their meso- structural integrity and dimensional stability has become an attractive and interesting challenge in biomaterials science. We present a postgrafting strategy for introducing different metal elements into MBG NPs. This strategy is mediated by polydopamine (PDA) coating, achieving uniform loading of copper or copper-cobalt on the particles efficiently and ensuring the stability of MBG NPs in terms of particle size, mesoporous structure, and chemical structure. However, the PDA coating reduced the ion-binding free energy of the MBG NPs for calcium and phosphate ions, resulting in the deposition of minimal CaP clusters on the PDA@MBG NP surface when immersed for 7 days in simulated body fluid, indicating the absence of hydroxyapatite mineralization.

AB - Exploring new approaches to realize the possibility of incorporating biologically active elements into mesoporous silicate bioactive glass nanoparticles (MBG NPs) and guaranteeing their meso- structural integrity and dimensional stability has become an attractive and interesting challenge in biomaterials science. We present a postgrafting strategy for introducing different metal elements into MBG NPs. This strategy is mediated by polydopamine (PDA) coating, achieving uniform loading of copper or copper-cobalt on the particles efficiently and ensuring the stability of MBG NPs in terms of particle size, mesoporous structure, and chemical structure. However, the PDA coating reduced the ion-binding free energy of the MBG NPs for calcium and phosphate ions, resulting in the deposition of minimal CaP clusters on the PDA@MBG NP surface when immersed for 7 days in simulated body fluid, indicating the absence of hydroxyapatite mineralization.

KW - biomineralization

KW - mesoporous bioactive glass

KW - metal-ion loading

KW - molecular dynamics simulation

KW - polydopamine coating

UR - http://www.scopus.com/inward/record.url?scp=85162866431&partnerID=8YFLogxK

U2 - 10.1021/acsami.3c03680

DO - 10.1021/acsami.3c03680

M3 - Journal Article (refereed)

C2 - 37278380

AN - SCOPUS:85162866431

SN - 1944-8244

VL - 15

SP - 29550

EP - 29560

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 24

ER -

Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity

Abstract

Bibliographical note

Funding

Keywords

Access to Document

Other files and links

Fingerprint

Cite this