Mussel-Inspired Polydopamine Composite Mesoporous Bioactive Glass Nanoparticles: An Exploration of Potential Metal-Ion Loading Platform and In Vitro Bioactivity

Baiyan SUI, Zhiyan XU, Zhiyu XUE, Yong XIANG, Tian ZHOU, Ana M. BELTRÁN, Kai ZHENG*, Xin LIU*, Aldo R. BOCCACCINI*

*Corresponding author for this work

Research output: Journal PublicationsJournal Article (refereed)peer-review

1 Citation (Scopus)

Abstract

Exploring new approaches to realize the possibility of incorporating biologically active elements into mesoporous silicate bioactive glass nanoparticles (MBG NPs) and guaranteeing their meso- structural integrity and dimensional stability has become an attractive and interesting challenge in biomaterials science. We present a postgrafting strategy for introducing different metal elements into MBG NPs. This strategy is mediated by polydopamine (PDA) coating, achieving uniform loading of copper or copper-cobalt on the particles efficiently and ensuring the stability of MBG NPs in terms of particle size, mesoporous structure, and chemical structure. However, the PDA coating reduced the ion-binding free energy of the MBG NPs for calcium and phosphate ions, resulting in the deposition of minimal CaP clusters on the PDA@MBG NP surface when immersed for 7 days in simulated body fluid, indicating the absence of hydroxyapatite mineralization.

Original languageEnglish
Pages (from-to)29550-29560
Number of pages11
JournalACS Applied Materials and Interfaces
Volume15
Issue number24
Early online date6 Jun 2023
DOIs
Publication statusPublished - 21 Jun 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 American Chemical Society.

Keywords

  • biomineralization
  • mesoporous bioactive glass
  • metal-ion loading
  • molecular dynamics simulation
  • polydopamine coating

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