Profiling of mass spectrometry data for ovarian cancer detection using negative correlation learning

Shan HE, Huanhuan CHEN, Xiaoli LI, Xin YAO

Research output: Book Chapters | Papers in Conference ProceedingsConference paper (refereed)Researchpeer-review

Abstract

This paper proposes a novel Mass Spectrometry data profiling method for ovarian cancer detection based on negative correlation learning (NCL). A modified Smoothed Nonlinear Energy Operator (SNEO) and correlation-based peak selection were applied to detected informative peaks for NCL to build a prediction model. In order to evaluate the performance of this novel method without bias, we employed randomization techniques by dividing the data set into testing set and training set to test the whole procedure for many times over. The classification performance of the proposed approach compared favorably with six machine learning algorithms. © 2009 Springer Berlin Heidelberg.
Original languageEnglish
Title of host publicationArtificial Neural Networks : ICANN 2009 19th International Conference, Limassol, Cyprus, September 14-17, 2009, Proceedings, Part II
EditorsCesare APLIPPI, Marios POLYCARPOU, Christos PANAYIOTOU, Georgios ELLINAS
PublisherSpringer Berlin Heidelberg
Pages185-194
Number of pages10
ISBN (Electronic)9783642042775
ISBN (Print)9783642042768
DOIs
Publication statusPublished - 2009
Externally publishedYes
Event19th International Conference on Artificial Neural Networks, ICANN 2009 - Limassol, Cyprus
Duration: 14 Sept 200917 Sept 2009

Publication series

NameLecture Notes in Computer Science
PublisherSpringer Berlin, Heidelberg
Volume5769
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference19th International Conference on Artificial Neural Networks, ICANN 2009
Country/TerritoryCyprus
CityLimassol
Period14/09/0917/09/09

Keywords

  • Bioinformatics
  • Data mining
  • Negative correlation learning
  • Proteomics

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