Influenza virus infection is a major health care concern associated with significant morbidity and mortality worldwide, and cause annual seasonal epidemics and pandemics at irregular intervals. Recent research has highlighted that viral components can be found on the extracellular vesicles (EVs) released from infected cells, implying a functional relevance of EVs with influenza virus dissemination. Therefore, exploring the role of EVs in influenza virus infection has been attracting significant attention. In this review, we will briefly introduce the biogenesis of EVs, and focus on the role of EVs in influenza virus infection, and then discuss the EVs-based influenza vaccines and the limitations of EVs studies, to further enrich and boost the development of preventative and therapeutic strategies to combat influenza virus.
Bibliographical noteThis work was supported by the grants from a scientific research project of Sichuan Education Department of China (no. 18ZB0171), Research Project of Chengdu Medical College (CYZ17-27), Science and Technology Project of Guangdong Province (2017B090911012), and Funds of Talents for High-level University in the Construction of Guangzhou Medical University (no. B195002009025).
- extracellular vesicles
- immune response
- influenza virus