SEENS: Nuclei segmentation in Pap smear images with selective edge enhancement

Meng ZHAO*, Hao WANG, Ying HAN, Xiaokang WANG, Hong Ning DAI, Xuguo SUN, Jin ZHANG, Marius PEDERSEN

*Corresponding author for this work

Research output: Journal PublicationsJournal Article (refereed)peer-review

8 Citations (Scopus)

Abstract

Accurate nuclei segmentation, as an indispensable basis and core link for multi-cell cervical image analysis, plays an important role in automatic pre-cancer detection. However, poor image quality due to the uneven staining, complex backgrounds and overlapped cell clusters poses a great challenge in nuclei segmentation. In this paper, we propose a new Selective-Edge-Enhancement-based Nuclei Segmentation method (SEENS). In the proposed method, selective search is integrated with mathematical operators to segment whole slide cervical images into small regions of interest (ROI) while automatically avoiding repeated segmentation as well as eliminating non-nuclei regions. In addition, an edge enhancement method based on the canny operator and mathematical morphology is presented to extract edge information as a weight to enhance the nucleus edge selectively. As a result, the enhanced ROI is then segmented by the Chan–Vese model with a higher accuracy. We evaluate our method with 18 whole slide images for a total of 395 cell nuclei. Experimental results demonstrate that SEENS achieves higher accuracy in cervical nuclei segmentation. Notably our method performs particularly better in low-contrast scenarios than baselines.

Original languageEnglish
Pages (from-to)185-194
Number of pages10
JournalFuture Generation Computer Systems
Volume114
Early online date30 Jul 2020
DOIs
Publication statusPublished - Jan 2021
Externally publishedYes

Bibliographical note

Funding Information:
Dr. Zhao’s awards and honors include the ERCIM “Alain Bensoussan Fellowship Programme” and the “131 Training Plan for Innovative Talents of Tianjin”.

Funding Information:
This document is the results of the research project funded by the National Science Foundation of China (Grant Nos. 61703304 , 61906133 and U1509207 ), R & D Plan in Key Field of Guangdong Province (Grant No. 2019B010109001 ), Major Science and Technology Projects of Tianjin (Grant No. 18ZXZNGX00150 ) and is carried out with the support of ERCIM ‘Alain Bensoussan’ Fellowship Programme ”.

Funding Information:
This document is the results of the research project funded by the National Science Foundation of China (Grant Nos. 61703304, 61906133 and U1509207), R & D Plan in Key Field of Guangdong Province (Grant No. 2019B010109001), Major Science and Technology Projects of Tianjin (Grant No. 18ZXZNGX00150) and is carried out with the support of ERCIM ?Alain Bensoussan? Fellowship Programme ?.

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

  • Canny operator
  • Chan–Vese model
  • Nuclei segmentation
  • Selective edge enhancement
  • Selective search

Fingerprint

Dive into the research topics of 'SEENS: Nuclei segmentation in Pap smear images with selective edge enhancement'. Together they form a unique fingerprint.

Cite this