Self-assembled polymer membrane capsules inflated by osmotic pressure

Vernita D. GORDON, Xi CHEN, John W. HUTCHINSON, Andreas R. BAUSCH, Manuel MARQUEZ, David A. WEITZ

Research output: Journal PublicationsJournal Article (refereed)peer-review

117 Citations (Scopus)

Abstract

We fabricate and characterize capsules that are composite membranes, made of a polymer network stabilized by adsorption to colloids and inflated by osmotic pressure from internal free polyelectrolyte; here, poly-L-lysine forms the network and inflates the capsules. To assess these capsules' properties and structure, we deform capsules using microcantilevers and use finite element modeling to describe these deformations. Additional experimental tests confirm the model's validity. These capsules' resilient response to mechanical forces indicates that loading and shear should be good triggers for the release of contents via deformation. The osmotic pressure inflating these capsules has the potential to trigger release of contents via deflation in response to changes in the capsules' environment; we demonstrate addition of salt as a trigger for deflating capsules. Because these capsules have a variety of release triggers available and the technique used to fabricate them is very flexible and allows high encapsulation efficiency, these capsules have very high potential for application in many areas.
Original languageEnglish
Pages (from-to)14117-14122
Number of pages6
JournalJournal of the American Chemical Society
Volume126
Issue number43
Early online date12 Oct 2004
DOIs
Publication statusPublished - 1 Nov 2004
Externally publishedYes

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