Tetrahedral Framework Nucleic Acids Inhibit Muscular Mitochondria-Mediated Apoptosis and Ameliorate Muscle Atrophy in Sarcopenia

Xi YU; Yun WANG; Liyu RAN; Yang JIANG; Ming CHEN; Hao DU; Yao ZHANG; Diwei WU; Xiaona XIANG; Jiawei ZHANG; Ning JIANG; Hongchen HE; Yueming SONG; Zhou XIANG; Chengqi HE; Zongke ZHOU; Jiancheng ZENG; Yong XIANG; Shi Shu HUANG; Yunfeng LIN

doi:10.1021/acs.nanolett.3c01502

Tetrahedral Framework Nucleic Acids Inhibit Muscular Mitochondria-Mediated Apoptosis and Ameliorate Muscle Atrophy in Sarcopenia

Xi YU, Yun WANG, Liyu RAN, Yang JIANG, Ming CHEN, Hao DU, Yao ZHANG, Diwei WU, Xiaona XIANG, Jiawei ZHANG, Ning JIANG, Hongchen HE, Yueming SONG, Zhou XIANG, Chengqi HE, Zongke ZHOU, Jiancheng ZENG, Yong XIANG, Shi Shu HUANG^*, Yunfeng LIN^*

^*Corresponding author for this work

Research output: Journal Publications › Journal Article (refereed) › peer-review

5 Citations (Scopus)

Abstract

Sarcopenia is known as age-related muscle atrophy, which influences over a quarter of the elderly population worldwide. It is characterized by a progressive decline in muscle mass, strength, and performance. To date, clinical treatments in sarcopenia are limited to rehabilitative interventions and dietary supplements. Tetrahedral framework nucleic acids (tFNAs) represent a novel kind of DNA-based nanomaterial with superior antiapoptosis capacity in cells, tissues, organs, and systems. In our study, the therapeutic effect of tFNAs treatment on sarcopenia was evaluated both in vivo and in vitro. Results from muscular biophysiological characteristics demonstrated significant improvement in muscle function and endurance in the aged mouse model, and histologic examinations also showed beneficial morphological changes in muscle fibers. In vitro, DEX-induced sarcopenic myotube atrophy was also ameliorated through the inhibition of mitochondria-mediated cell apoptosis. Collectively, tFNAs treatment might serve as an alternative option to deal with sarcopenia in the near future.

Original language	English
Pages (from-to)	8816-8826
Number of pages	11
Journal	Nano Letters
Volume	23
Issue number	18
Early online date	17 Jul 2023
DOIs	https://doi.org/10.1021/acs.nanolett.3c01502
Publication status	Published - 27 Sept 2023
Externally published	Yes

Bibliographical note

We sincerely appreciate Li Chai, Yi Li, Xing Xu, from the Core Facilities, West China Hospital, Sichuan University, for their assistance. This work was supported by National Natural Science Foundation of China (No. 81874027); Shenzhen–Hong Kong Institute of Brain Science–Shenzhen Fundamental Research Institutions (No. 312200102); Science & Technology Department of Sichuan Province (Nos. 2021YFSY0003, 2022YFS0051, 2022NSFSC1312, 2023NSFSC1607); 135-project for disciplines of excellence, West China Hospital, Sichuan University (No. 2021HXFH036).

Keywords

apoptosis
mitochondria
muscle atrophy
sarcopenia
tetrahedral framework nucleic acids

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10.1021/acs.nanolett.3c01502

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YU, X., WANG, Y., RAN, L., JIANG, Y., CHEN, M., DU, H., ZHANG, Y., WU, D., XIANG, X., ZHANG, J., JIANG, N., HE, H., SONG, Y., XIANG, Z., HE, C., ZHOU, Z., ZENG, J., XIANG, Y., HUANG, S. S., & LIN, Y. (2023). Tetrahedral Framework Nucleic Acids Inhibit Muscular Mitochondria-Mediated Apoptosis and Ameliorate Muscle Atrophy in Sarcopenia. Nano Letters, 23(18), 8816-8826. https://doi.org/10.1021/acs.nanolett.3c01502

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title = "Tetrahedral Framework Nucleic Acids Inhibit Muscular Mitochondria-Mediated Apoptosis and Ameliorate Muscle Atrophy in Sarcopenia",

abstract = "Sarcopenia is known as age-related muscle atrophy, which influences over a quarter of the elderly population worldwide. It is characterized by a progressive decline in muscle mass, strength, and performance. To date, clinical treatments in sarcopenia are limited to rehabilitative interventions and dietary supplements. Tetrahedral framework nucleic acids (tFNAs) represent a novel kind of DNA-based nanomaterial with superior antiapoptosis capacity in cells, tissues, organs, and systems. In our study, the therapeutic effect of tFNAs treatment on sarcopenia was evaluated both in vivo and in vitro. Results from muscular biophysiological characteristics demonstrated significant improvement in muscle function and endurance in the aged mouse model, and histologic examinations also showed beneficial morphological changes in muscle fibers. In vitro, DEX-induced sarcopenic myotube atrophy was also ameliorated through the inhibition of mitochondria-mediated cell apoptosis. Collectively, tFNAs treatment might serve as an alternative option to deal with sarcopenia in the near future.",

keywords = "apoptosis, mitochondria, muscle atrophy, sarcopenia, tetrahedral framework nucleic acids",

author = "Xi YU and Yun WANG and Liyu RAN and Yang JIANG and Ming CHEN and Hao DU and Yao ZHANG and Diwei WU and Xiaona XIANG and Jiawei ZHANG and Ning JIANG and Hongchen HE and Yueming SONG and Zhou XIANG and Chengqi HE and Zongke ZHOU and Jiancheng ZENG and Yong XIANG and HUANG, {Shi Shu} and Yunfeng LIN",

note = "We sincerely appreciate Li Chai, Yi Li, Xing Xu, from the Core Facilities, West China Hospital, Sichuan University, for their assistance. This work was supported by National Natural Science Foundation of China (No. 81874027); Shenzhen–Hong Kong Institute of Brain Science–Shenzhen Fundamental Research Institutions (No. 312200102); Science & Technology Department of Sichuan Province (Nos. 2021YFSY0003, 2022YFS0051, 2022NSFSC1312, 2023NSFSC1607); 135-project for disciplines of excellence, West China Hospital, Sichuan University (No. 2021HXFH036).",

year = "2023",

month = sep,

day = "27",

doi = "10.1021/acs.nanolett.3c01502",

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YU, X, WANG, Y, RAN, L, JIANG, Y, CHEN, M, DU, H, ZHANG, Y, WU, D, XIANG, X, ZHANG, J, JIANG, N, HE, H, SONG, Y, XIANG, Z, HE, C, ZHOU, Z, ZENG, J, XIANG, Y, HUANG, SS & LIN, Y 2023, 'Tetrahedral Framework Nucleic Acids Inhibit Muscular Mitochondria-Mediated Apoptosis and Ameliorate Muscle Atrophy in Sarcopenia', Nano Letters, vol. 23, no. 18, pp. 8816-8826. https://doi.org/10.1021/acs.nanolett.3c01502

TY - JOUR

T1 - Tetrahedral Framework Nucleic Acids Inhibit Muscular Mitochondria-Mediated Apoptosis and Ameliorate Muscle Atrophy in Sarcopenia

AU - YU, Xi

AU - WANG, Yun

AU - RAN, Liyu

AU - JIANG, Yang

AU - CHEN, Ming

AU - DU, Hao

AU - ZHANG, Yao

AU - WU, Diwei

AU - XIANG, Xiaona

AU - ZHANG, Jiawei

AU - JIANG, Ning

AU - HE, Hongchen

AU - SONG, Yueming

AU - XIANG, Zhou

AU - HE, Chengqi

AU - ZHOU, Zongke

AU - ZENG, Jiancheng

AU - XIANG, Yong

AU - HUANG, Shi Shu

AU - LIN, Yunfeng

N1 - We sincerely appreciate Li Chai, Yi Li, Xing Xu, from the Core Facilities, West China Hospital, Sichuan University, for their assistance. This work was supported by National Natural Science Foundation of China (No. 81874027); Shenzhen–Hong Kong Institute of Brain Science–Shenzhen Fundamental Research Institutions (No. 312200102); Science & Technology Department of Sichuan Province (Nos. 2021YFSY0003, 2022YFS0051, 2022NSFSC1312, 2023NSFSC1607); 135-project for disciplines of excellence, West China Hospital, Sichuan University (No. 2021HXFH036).

PY - 2023/9/27

Y1 - 2023/9/27

N2 - Sarcopenia is known as age-related muscle atrophy, which influences over a quarter of the elderly population worldwide. It is characterized by a progressive decline in muscle mass, strength, and performance. To date, clinical treatments in sarcopenia are limited to rehabilitative interventions and dietary supplements. Tetrahedral framework nucleic acids (tFNAs) represent a novel kind of DNA-based nanomaterial with superior antiapoptosis capacity in cells, tissues, organs, and systems. In our study, the therapeutic effect of tFNAs treatment on sarcopenia was evaluated both in vivo and in vitro. Results from muscular biophysiological characteristics demonstrated significant improvement in muscle function and endurance in the aged mouse model, and histologic examinations also showed beneficial morphological changes in muscle fibers. In vitro, DEX-induced sarcopenic myotube atrophy was also ameliorated through the inhibition of mitochondria-mediated cell apoptosis. Collectively, tFNAs treatment might serve as an alternative option to deal with sarcopenia in the near future.

AB - Sarcopenia is known as age-related muscle atrophy, which influences over a quarter of the elderly population worldwide. It is characterized by a progressive decline in muscle mass, strength, and performance. To date, clinical treatments in sarcopenia are limited to rehabilitative interventions and dietary supplements. Tetrahedral framework nucleic acids (tFNAs) represent a novel kind of DNA-based nanomaterial with superior antiapoptosis capacity in cells, tissues, organs, and systems. In our study, the therapeutic effect of tFNAs treatment on sarcopenia was evaluated both in vivo and in vitro. Results from muscular biophysiological characteristics demonstrated significant improvement in muscle function and endurance in the aged mouse model, and histologic examinations also showed beneficial morphological changes in muscle fibers. In vitro, DEX-induced sarcopenic myotube atrophy was also ameliorated through the inhibition of mitochondria-mediated cell apoptosis. Collectively, tFNAs treatment might serve as an alternative option to deal with sarcopenia in the near future.

KW - apoptosis

KW - mitochondria

KW - muscle atrophy

KW - sarcopenia

KW - tetrahedral framework nucleic acids

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U2 - 10.1021/acs.nanolett.3c01502

DO - 10.1021/acs.nanolett.3c01502

M3 - Journal Article (refereed)

C2 - 37459451

AN - SCOPUS:85166655013

SN - 1530-6984

VL - 23

SP - 8816

EP - 8826

JO - Nano Letters

JF - Nano Letters

IS - 18

ER -

Tetrahedral Framework Nucleic Acids Inhibit Muscular Mitochondria-Mediated Apoptosis and Ameliorate Muscle Atrophy in Sarcopenia

Abstract

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Keywords

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