Ultrasound-responsive materials for drug/gene delivery

Xiaowen CAI; Yuan JIANG; Mei LIN; Jiyong ZHANG; Huanhuan GAO; Fanwen YANG; Wingnang LEUNG; Chuanshan XU

doi:10.3389/fphar.2019.01650

Ultrasound-responsive materials for drug/gene delivery

Xiaowen CAI, Yuan JIANG, Mei LIN, Jiyong ZHANG, Huanhuan GAO, Fanwen YANG, Wingnang LEUNG^*, Chuanshan XU^*

^*Corresponding author for this work

Asia-Pacific Institute of Ageing Studies

Research output: Journal Publications › Review article › Other Review

76 Citations (Scopus)

Abstract

Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of drugs/genes and attracts increasing attention. Microbubbles are the most well-known ultrasound-responsive delivery materials. Recently, nanobubbles, droplets, micelles, and nanoliposomes have been developed as novel carriers in this field. Herein, we review advances of novel ultrasound-responsive materials (nanobubbles, droplets, micelles and nanoliposomes) and discuss the challenges of ultrasound-responsive materials in delivery systems to boost the development of ultrasound-responsive materials as delivery carriers.

Original language	English
Article number	1650
Journal	Frontiers in Pharmacology
Volume	10
DOIs	https://doi.org/10.3389/fphar.2019.01650
Publication status	Published - 31 Jan 2020

Bibliographical note

The datasets generated for this study can be found in the ClinicalTrials.gov database (https://clinicaltrials.gov/).

This work was supported by the Fund of Talents for High-level University in the Construction of Guangzhou (B195002009025) and the Science and Technology Project of Guangdong Province (2017B090911012).

We express our sincere gratitude to Dr. Qicai Xiao for the helpful assistance.

Keywords

Delivery
Drug
Gene
Microbubbles
Ultrasound-responsive materials

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10.3389/fphar.2019.01650Licence: CC BY

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abstract = "Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of drugs/genes and attracts increasing attention. Microbubbles are the most well-known ultrasound-responsive delivery materials. Recently, nanobubbles, droplets, micelles, and nanoliposomes have been developed as novel carriers in this field. Herein, we review advances of novel ultrasound-responsive materials (nanobubbles, droplets, micelles and nanoliposomes) and discuss the challenges of ultrasound-responsive materials in delivery systems to boost the development of ultrasound-responsive materials as delivery carriers.",

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note = "The datasets generated for this study can be found in the ClinicalTrials.gov database (https://clinicaltrials.gov/). This work was supported by the Fund of Talents for High-level University in the Construction of Guangzhou (B195002009025) and the Science and Technology Project of Guangdong Province (2017B090911012). We express our sincere gratitude to Dr. Qicai Xiao for the helpful assistance.",

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AU - CAI, Xiaowen

AU - JIANG, Yuan

AU - LIN, Mei

AU - ZHANG, Jiyong

AU - GAO, Huanhuan

AU - YANG, Fanwen

AU - LEUNG, Wingnang

AU - XU, Chuanshan

N1 - The datasets generated for this study can be found in the ClinicalTrials.gov database (https://clinicaltrials.gov/). This work was supported by the Fund of Talents for High-level University in the Construction of Guangzhou (B195002009025) and the Science and Technology Project of Guangdong Province (2017B090911012). We express our sincere gratitude to Dr. Qicai Xiao for the helpful assistance.

PY - 2020/1/31

Y1 - 2020/1/31

N2 - Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of drugs/genes and attracts increasing attention. Microbubbles are the most well-known ultrasound-responsive delivery materials. Recently, nanobubbles, droplets, micelles, and nanoliposomes have been developed as novel carriers in this field. Herein, we review advances of novel ultrasound-responsive materials (nanobubbles, droplets, micelles and nanoliposomes) and discuss the challenges of ultrasound-responsive materials in delivery systems to boost the development of ultrasound-responsive materials as delivery carriers.

AB - Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of drugs/genes and attracts increasing attention. Microbubbles are the most well-known ultrasound-responsive delivery materials. Recently, nanobubbles, droplets, micelles, and nanoliposomes have been developed as novel carriers in this field. Herein, we review advances of novel ultrasound-responsive materials (nanobubbles, droplets, micelles and nanoliposomes) and discuss the challenges of ultrasound-responsive materials in delivery systems to boost the development of ultrasound-responsive materials as delivery carriers.

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KW - Drug

KW - Gene

KW - Microbubbles

KW - Ultrasound-responsive materials

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Ultrasound-responsive materials for drug/gene delivery

Abstract

Bibliographical note

Keywords

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