Abstract
Ultrasound is one of the most commonly used methods in the diagnosis and therapy of diseases due to its safety, deep penetration into tissue, and non-invasive nature. In the drug/gene delivery systems, ultrasound shows many advantages in terms of site-specific delivery and spatial release control of drugs/genes and attracts increasing attention. Microbubbles are the most well-known ultrasound-responsive delivery materials. Recently, nanobubbles, droplets, micelles, and nanoliposomes have been developed as novel carriers in this field. Herein, we review advances of novel ultrasound-responsive materials (nanobubbles, droplets, micelles and nanoliposomes) and discuss the challenges of ultrasound-responsive materials in delivery systems to boost the development of ultrasound-responsive materials as delivery carriers.
Original language | English |
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Article number | 1650 |
Journal | Frontiers in Pharmacology |
Volume | 10 |
DOIs | |
Publication status | Published - 31 Jan 2020 |
Bibliographical note
The datasets generated for this study can be found in the ClinicalTrials.gov database (https://clinicaltrials.gov/).We express our sincere gratitude to Dr. Qicai Xiao for the helpful assistance.
Funding
This work was supported by the Fund of Talents for High-level University in the Construction of Guangzhou (B195002009025) and the Science and Technology Project of Guangdong Province (2017B090911012).
Keywords
- Delivery
- Drug
- Gene
- Microbubbles
- Ultrasound-responsive materials